为了进一步阐明 FDX1 过表达对肾透明细胞癌表型的抑制作用，研究人员成功构建了小鼠原位肾肿瘤生长模型。研究结果表明，与对照组相比，FDX1 过表达组的 EdU 表达显著降低，而 TUNEL 表达显著升高。H&E 染色结果显示，FDX1 过表达组的肺转移灶数量明显少于对照组。此外，与对照组相比，FDX1 过表达组肺转移灶中 E-钙黏蛋白的表达显著增加，而 N-钙黏蛋白的表达显著降低。

Northwestern Medicine investigators have uncovered new insights into how intercellular "glue" functions to enable ...

研究人员通过分析 TCGA 数据库，发现 miR-101-3p 在肝癌组织中的表达低于正常组织，且其低表达与肝癌患者的不良预后相关。在临床样本和细胞系中也证实了这一点，像 QGY7701 和 HepG2 这些肝癌细胞系中 miR-101-3p 的表达明显低于正常细胞。

CHARLOTTE, N.C. — Adam Wurtzel invited Evelyn Harris of Leena’s Eats Catering, the winner of Charlotte’s Sip & Soup Festival into the studio to sample her award winning soup. Harris cooked up a Smoked ...

We investigated the early (24-hour) changes in spatial gene expression in the brain parenchymal endothelial cells and mural cells following ischemia stroke reperfusion in 13- to 14-week-old C57BL/6JRj ...

For T-cadherin overexpression, we employed the pcDNA3.1-DsRed-Tcad plasmid encoding human CDH13 cDNA, a kind gift from the Laboratory of Cellular Engineering led by T.N. Vlasik, at the Federal State ...

PRAGUE, Czech Republic and LONDON, UK I March 03, 2025 I SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, today presented the first preclinical data on SOT109, a novel ...

They proposed that treatment with the ketone body D-β- hydroxybutyrate (β-HB) may inhibit glycolytic-lactate metabolism and suppress the B-raf/mitogen-activated protein kinase (MAPK) pathway and the ...