Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

But this mechanism motivates the capture of more glucose for the synthesis of further ATP molecules. There is also activation of the pentose phosphate (PPP) pathway that produces ribose and NADPH. The ...

During liver damage repair, the circadian clock in the liver is shown to act together with HIF-1α signalling to regulate pentose phosphate pathway activity and nucleotide availability.

By increasing glycolytic enzyme expression, mTOR complex 1 (mTORC1) supports cellular growth by modulating the balance between oxidative phosphorylation and glycolysis, increasing the activity of the ...

Enrichment analysis revealed that Ang-II induced HTN causes significant metabolic shift in the brain by altering the pathways which are involved in glycolysis/gluconeogenesis (false discovery rate ...

生物节律钟在细胞内调控着一系列关键的生命进程，如细胞周期、DNA修复和能量代谢，这些过程与衰老密切相关。然而，科学界对于机体在组织损伤和修复过程中如何适应性调节核苷酸含量的机制仍知之甚少。 近日，中国药科大学生命科学与技术学院的钱民先/王中原团队在《自然-代谢》（Nature Metabolism）杂志上发表了一项重要研究，题为“The hepatic clock synergizes with ...

Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 301700, ...

这项研究揭示了肝脏内部生物钟控制着磷酸戊糖途径（Pentose Phosphate Pathway, PPP）的节律性波动，并通过调整PPP活性以满足肝损伤修复过程中对核苷酸 ...

该研究揭示了肝脏内部生物钟通过调控磷酸戊糖途径（Pentose Phosphate Pathway, PPP）来满足肝损伤修复时对核苷酸从头合成的需求。 研究人员利用代谢组 ...

Anna Hirsch has now taken a closer look at a less obvious difference between bacteria and humans that has not yet been pharmaceutically exploited: the so-called methylerythritol phosphate pathway ...

Department of Cardiology, The Affiliated Hospital of Qingdao University, China; Department of Urology, The Affiliated Hospital of Qingdao University, China; ...