Immunizing the host with a piece of viral DNA rather than an antigenic protein fragment of the virus, helps to stimulate the generation of cell-mediated immunity (Fig. 2). DNA vaccines contain the ...

This approach uses co-infection with a transgene-containing vector and a second vector encoding multiple enhancer sequences. Using this cis-activation strategy in primary cells and muscle ...

The following table lists the recommended amount of DNA template and primer for optimal Sanger sequencing results. Note: for plasmid DNA the size is the entire plasmid, vector plus insert. For plasmid ...

VectorBuilder's partner, Ucello, announced that its CD19-targeting umbilical cord blood-derived allogeneic CAR-T cell therapy ...

The student researchers found that one of four vials of experimental vaccines contained residual plasmid DNA, a small circular DNA molecule found in bacteria that gets used during vaccine ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

codon-optimized amplicons ranging from AchPV2-F 1-488 or WENV-GP 1-428 were cloned upstream of a mammalian plasmid vector containing a HIV1281 (PDB ID 3P30) trimerisation motif according to the ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Cell line development plays a pivotal role in the manufacturing of therapeutic proteins, vaccines and other biologics.

After administration of the DNA, antigens are produced and stimulate an immune response. Mathot et al. assess stability of an adenovirus-based vaccine vector lyophilized and stored long-term.

This production strategy does not require plasmid DNA as critical starting material ... strong potency of the lentiviral vector. Incorporating an advanced design for gene editing, UC101 minimizes ...