The characteristic diagnostic signs of prion disease in humans and animals, such as changes in behavior and mobility, result from advanced neurodegeneration for which there is currently no cure.

Human prion disease, also called Creutzfeldt-Jakob disease ... "Basically, you take the patient's CSF, mix it with a ...

and Creutzfeldt–Jakob disease (CJD) in humans. In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for ...

Researchers find that tumor stem cells became less able to proliferate and invade tissues when gene editing blocked the ...

Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

Led by a team at the Broad Institute, the new gene therapy aims to address the root cause of prion disease by using the CHARM (Coupled Histone tail for Autoinhibition Release of Methyltransferase) ...