Eye diseases often develop asymptomatically for many years. ICTER scientists have developed the f-ORG technique, which ...

Light is a powerful source of energy that is used for various biological purposes. Some organisms harness light to produce ATP, the energy currency of cells, while others use light to interpret ...

At the heart of this issue is the protein rhodopsin, which, due to genetic mutations, often misfolds. This misfolding disrupts its function, leading to retinal cell degeneration. Scientists have ...

This study makes the fundamental discovery of the first natural animal rhodopsin that uses a chloride ion instead of an amino acid side chain as a counterion. Using a combination of biochemical and ...

delivered the AIPL1 coding sequence using a human rhodopsin kinase promoter. Oral prednisolone was administered perioperatively to mitigate inflammation. Visual acuity, functional vision, retinal ...

The first optogenetic "Chimeric Rhodopsin" gene therapy tested in humans. RV-001 starting dose was generally well tolerated in this open-label trial. RV-001 a gene-agnostic approach for RP patients.

In addition to being the chromophore that absorbs light in the rhodopsin molecule, his research demonstrates that vitamin A controls transcription of genes relevant to vision. Zeaxanthin and lutein ...

The first optogenetic "Chimeric Rhodopsin" gene therapy tested in humans ... a clinical-stage gene therapy company, specializes in developing transformative gene therapies for inherited retinal ...