T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has ...

A different picture emerges in the context of chronic infection or cancer where the persistence of Ags and inflammation lead to a state of T cell exhaustion. In the second part of this review, we will ...

Abstract Research of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM), two acquired chronic illnesses affecting mainly females, has failed to ascertain their frequent ...

Iron deficiency can cause several symptoms, including fatigue, headaches, and brittle nails. Spotting these signs early on ...

This symptom can also be accompanied by acute chest syndrome.” Fatigue: As sickle cells cannot carry oxygen properly, chronic fatigue is mostly present. Lower respiratory tract infections (LRTIs ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

View Full Profile. Learn about our Editorial Policies. Chimeric antigen receptor (CAR) T cell therapy leverages patients’ immune systems to fight cancer. This immunotherapy greatly expanded treatment ...

The term “heart failure” sounds as if the heart has stopped working. Although it’s a serious condition and requires timely medical attention, the words actually mean that the heart isn’t able to keep ...

July 22, 2024 — The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for ...

Managing diabetes is even harder when temperatures and humidity are rising. Find out how extreme heat can negatively affect ...

WHEN Chloe Broad split from her boyfriend last year, she was heartbroken. Like many of us after a break-up, she was stressed, exhausted, and spent hours upon hours every week “just moping ...

A small but in-depth study of allogeneic CAR T cell therapy in patients with high-risk neuroblastoma shows feasibility and potential efficacy, and mechanistic insights reveal pathways to improved ...