Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders—T cells—lose their ability to function effectively.

CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders – T cells – lose their ability to function effectively.

The response of PBMC in space shares T-cell exhaustion features, likely initiated by microgravity than by infection. Consequences of mitochondria dysfunction include immune dysregulation and prolonged ...

a state called stem cell exhaustion. (3) These observations support the stem cell theory of aging, which suggests that aging results from the inability of tissue-specific stem cells to replenish ...