Immune dysfunction during chronic infections and cancer leads to disease progression due to T cell exhaustion. In this process, CD8 + T cells fail to form functional memory. T cell exhaustion results ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

The study showed that T-cells expressing the cell receptor CD38 were more susceptible to exhaustion. Using an anti-CD38 antibody, the research team was able to block CD38 and overcome T-cell ...

Basophils trigger a cytokine cascade that improves antitumor immunity in mice, offering potential targets for cancer immunotherapy.

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune ...

Expression of tissue factor (TF) in penile squamous cell carcinoma (PSCC) and enrichment in HPV-negative cases. This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium.

Chimeric antigen receptor T-cell therapy improves not only lupus disease activity but also other related conditions that ...