Macrophages represent one of the most prevalent cells in the colorectal cancer microenvironment and play a pivotal role in maintaining intestinal health and the development of colitis-associated colon ...

Males with pulmonary arterial hypertension (PAH) have more proinflammatory macrophages — a type of immune cell — in the lungs than do females with the disease, a study suggests. Researchers identified ...

Hence, IRP1 is highly abundant in the PTEC (91, 117) and regulates their iron content by synchronizing TfR1, DMT1 (uptake), FtH (for storage), and ferroportin (for export). Only two animal studies ...

When exposed to various stimuli, monocytes/macrophages are recruited to and retained within the local tissue microenvironment, where they can activate and display either proinflammatory or ...

This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers ...

Whether and how iron-specific proteins (Tfr1, Tfr2, transferrin, etc.) in non-hepatocyte cells regulate the crosstalk ... associated with ineffective erythropoiesis (i.e. β-thalassemia and MDS). Given ...

Our findings revealed that EGCG inhibited NEDD8, thus stabilizing HUWE1, a crucial E3 ubiquitin ligase involved in protein degradation. HUWE1 binds and degrades TFR1, a protein essential for cellular ...

Dyne leverages TfR1 Fab-conjugation for drug delivery to muscles. TfR1 is highly expressed in muscle cells. BMO analyst Kostas Biliouris acknowledges potential safety risks associated with TfR1 ...

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其次通过Western Blot检测TfR1-FPN1的蛋白含量实验，ICP-MS定量分析细胞内铁含量实验和转录组测序实验，进一步验证GaSₓ具有干扰铁代谢的潜力。 Figure 2. GaSx disrupted tumor cell iron metabolism. (a)Confocal images of CT26 cell endocytosis after GaSx ...