This downregulated T-cadherin expression correlated with the elevated levels of VE-cadherin and reduced levels of β-catenin, suggesting a disruption in endothelial cell-cell contact integrity and ...

研究结果 PG 缺失增强内皮屏障完整性：通过 TEER 测量发现，PG-KO 细胞的内皮屏障功能显著增强。免疫荧光分析显示，PG 缺失导致 VE-cadherin 和 β-catenin 向细胞连接处显著积累，其蛋白水平也明显升高，但 mRNA 水平未改变。此外，PG-KO 细胞中 PECAM-1 蛋白表达上调 ...

为探究淋巴管内皮细胞（LEC）维持机械稳定性的机制，研究人员开展相关研究，发现其形状的动态调节对淋巴管功能至关重要。 研究人员运用了多种关键技术方法。在实验动物模型方面，使用了多种基因工程小鼠，如 VE-cadherin-GFP 小鼠、iMb2-Mosaic 小鼠等，以便观察细胞和组织的特征 ...

To investigate how uPARAP regulates LEC–LEC junctions, we next assessed total VE cadherin level and its phosphorylation status (pY658 and pY685). However, neither total VE cadherin level nor its ...

Optimal growth conditions for HIMEC cultures were established, allowing up to nine passages (three months in vitro). The cells contained Weibel-Palade bodies, expressed von Willebrand factor, CD31, ...

这项研究发现，淋巴管内皮细胞通过精巧的细胞形态和动态调控的细胞骨架，有效地应对了液体压力变化带来的挑战，维持了淋巴管的完整性和功能。这些发现不仅加深了我们对淋巴系统基本生物学原理的理解，也为开发治疗淋巴系统相关疾病的新策略提供了潜在的靶点。

Ischemic stroke leads to a large number of pericyte death in the acute phase, while the number of pericytes gradually increases in the chronic phase of ischemia. Genetic tracing of cerebral ECs ...

The lobate shape of lymphatic endothelial cells puzzled researchers—now they’ve found it helps stabilize lymphatic ...

1 Acphazin Inc., Deerfield, IL, United States 2 College of Science, Health, and Pharmacy, Roosevelt University, Schaumburg, IL, United States Most early studies investigating the role of C-reactive ...