When a manuscript is ready for submission, please proceed to the manuscript submission site. Those manuscripts that are revised or ultimately accepted will be required to be formatted by the authors ...

Adequate venous drainage of brain parenchyma is essential to maintain cerebral perfusion and clearance of cerebrospinal fluid. The cortical vein opacification score (COVES) is a radiographic metric ...

This week please join author Kieran Docherty and Associate Editor Justin Ezekowitz as they discuss the article "Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure ...

The optimal grading scale must demonstrate (1) a strong correlation with clinical outcome, (2) simplicity and feasibility of scale interpretation while ensuring characterization of relevant ...

Figure 1. Signal transduction mechanism of EGFR (epidermal growth factor receptor) transactivation by angiotensin II (AngII) in vascular smooth muscle cells leading to vascular remodeling. Please note ...

Because of these effects, understanding the out-of-pocket costs for SGLT-2 inhibitors is essential. However, estimates for out-of-pocket costs are limited with no nationally representative or ...

The following terms are used in this article. Physical activity to refer to any bodily movement; exercise is used to indicate physical activity performed to stress primarily the oxygen transport ...

Arterial and venous thromboembolism are leading causes of morbidity and death worldwide. Despite significant advances in the diagnosis, prognostication, and treatment of thrombotic diseases over the ...

Level of Evidence: C=Limited populations evaluated. Only consensus opinion of experts, case studies, or standard of care; Fair=Benefits exceed the harms but quality of evidence is not as strong; 1+ = ...

Current guidelines lack recommendations regarding the use of proton pump inhibitors (PPIs) for preventing upper gastrointestinal bleeding (UGIB) among patients at low risk for UGIB treated with dual ...

All manuscripts should conform to one of the below article types and authors should note the length restrictions and other eligibility criteria for each type of article. Word limits for each ...