We identified several genes and pathways involved in the host response to infectious keratitis, including CXCL9, CXCR3, and MMP9 for viral, and S100A8/A9, MMP9, and the IL17 pathway for ...

By applying advanced single-cell multiomics techniques, they discovered key interactions between CXCL9/10 positive, CXCR2 positive macrophages, and CXCR3 high CD8 positive T-cells, which drive ...

Xenium In Situ（原位分析技术）是一种靶向检测技术。其工作原理是利用靶向探针在切片表面与目标转录本结合，然后通过循环扩增扩大目标转录本的信号。再利用Xenium分析仪在组织切片表面直接检测目标转录本信号，从而实现“原位测序”——即目标RNA无需从 ...

研究发现，TTFields 联合抗 PD-1 治疗在疗效和改善肿瘤免疫微环境方面表现更优，该联合治疗通过诱导肿瘤细胞发生 ICD，激活 IFN-γ 和 NF-κB 信号通路，进而增强 CCL2/8 - CCR2 轴和 CXCL9/10 - CXCR3 轴，招募 CD8 + T 细胞和 CD4 + T 细胞浸润，发挥抗肿瘤作用。CCL2/8 - CCR2 和 ...

33,34 In line with previous findings,35 circulating and tumour-infiltrating CTLs were found to express CCR5 and CXCR3 receptors (figure 5A), enabling them to respond to CCL5 and CXCL9/CXCL10, ...

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

Clinical and Radiographic Outcomes of Four Different Treatment Strategies in Patients With Early Rheumatoid Arthritis (the Best Study): A Randomized, Controlled Trialfrom Arthritis & Rheumatism ...