为解决晚期膀胱癌患者对免疫检查点抑制剂（ICI）反应难以预测的问题，研究人员开展多组学分析。他们发现相关关键因素并构建预测模型。该研究成果有助于推进晚期膀胱癌免疫治疗的精准医学，推荐科研读者阅读。 在癌症治疗的战场上，免疫检查点抑制剂 ...

本研究表明，sEVs中的CD98hc蛋白可作为监测淋巴瘤进展和耐药的临床标志物，为靶向肿瘤来源的sEVs和sEVs中的CD98hc蛋白治疗ENKTL提供了理论依据。

（五）CXCL9 和 CXCR3 与 N20 - CD8+T 及上皮内 CD3+T 细胞的相关性 对 39 例患者肿瘤样本进行单重免疫组化，发现 CXCL9 和 CXCR3 表达与 T 细胞在肿瘤微环境中的接近程度和浸润显著正相关，二者自身表达水平也显著正相关，但它们对 DFS 和 OS 无显著预后价值。 四、研究 ...

Both depletion of CXCL9/10+CCR2+ (C-C motif chemokine receptor) macrophages and CXCR3 blockade, respectively, led to decreased CXCR3hi CD8+ T-cell infiltration into the heart and significantly ...

该研究不仅推动了免疫学领域的新发展，还为临床实践带来了深远的启示。 研究团队提出联合靶向PD-1和CD155的治疗策略，不仅能够清除这些肿瘤起始 ...

Background: The tumor microenvironment (TME), which involves infiltration of multiple immune cells into the tumor tissues, plays an essential role in clinical benefit to therapy. The chemokines and ...

Autoimmune thyroiditis (AIT) is the most prevalent autoimmune endocrine disease, with a higher incidence in women than in men. Immunological abnormalities may lead to the impairment of ovarian ...

Tumor-associated dendritic cells (TADCs) can interact with tumor cells to suppress anti-tumor T cell immunity. However, there is no information on whether and how TADCs can modulate programmed ...