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生物通
27 天
过表达 Rap1:开启酿酒酵母高效生产三萜皂苷的新大门
酿酒酵母不仅能表达膜结合的真核细胞色素 P450 氧化酶(CYP450s,植物源产品如三萜类生物合成途径中的关键催化剂 ),产生的次生代谢产物还很少,而且它自身就有合成三萜皂苷关键前体 2,3 - 氧化角鲨烯(OSQ)的内源性途径,简直就是一个理想的 “生产工厂”。
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