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远志(PR)或为甲基苯丙胺成瘾治疗带来新希望:基于 TrkB/ERK 通路的 ...
WB 分析表明,单独使用 PR 可使前额叶皮层、伏隔核(nucleus accumbens,NAc)、尾状核壳(caudate putamen,CPu)中的 ERK 表达升高,使 CPu 中的 TrkB 表达升高。在发展阶段,PR 抑制了 CPu 中 METH 诱导的 TrkB/ERK 表达增加;在表达阶段,PR 减轻了 CPu 中 ERK 的升高。持续给予 ...
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