Heck, the MCU boasts multiple incarnations of Peter Parker all on its own. There’s the mainstream, Earth-616 version, played by Tom Holland, across various live-action MCU installments.
Peter Parker is a vehicle for the narrative, not the central focus. Supporting characters like Tombstone and Nico bring intrigue. Show's depth lies in exploring characters beyond Peter's story.
Sadie Sink's Spider-Man 4 character could offer interesting ways for Spidey and the MCU X-Men to connect despite a lack of comic history.