More information: Bin Xie et al, Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody, Nature Communications (2025). DOI: 10.1038/s41467-025-56478-6 Journal ...

P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

Bin Xie and Shipeng Xu, graduate students in biophysics and biomedical engineering at the University of California, Davis, with Professor Sanjeevi Sivasankar, carried out a series of experiments to ...

The researchers found that when the anti-cancer antibody binds to P-cadherin, it locks it into the X-dimer form. The stable X-form then triggers a chemical signal that causes that patch of ...

Additionally, ER cells showed increased cell-cell adhesion, linked to upregulated E-cadherin. E-cadherin was found to be vital for erlotinib resistance, largely independent of GRHL2, highlighting ...

Bin Xie and Shipeng Xu, graduate students in biophysics and biomedical engineering at the University of California, Davis, with Professor Sanjeevi Sivasankar, carried out a series of experiments to ...

BCANTT 2024: Dissecting the Impact of E-Cadherin Loss on the Immune Microenvironment BCANTT 2024: Exploring FGFR3 Inhibition as a Sensitizing Agent to Nectin-4 Antibody Drug Conjugate Therapy in ...