Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Misregulation of protein–protein interactions (PPIs) underlies many diseases; hence, ...

In still other cases, resistance to therapies is caused by further changes to mitochondrial metabolism that reduce treatment effectiveness. Examples of this include upregulating the anti-apoptotic ...

The team trained GPT-4b micro on protein sequences from various species and data about how proteins interact with each other. Similar to how ChatGPT completes sentences, this model suggests different ...

The method presents a strong foundation for broader applications in identifying physiologically and pharmacologically relevant membrane protein-ligand interactions. Integral membrane proteins ... 10 ...

Autophagosomes, the double membrane organelles forming upon nutrient ... Notably, core components in the ufmylation cascade, Ufl1 and Ufm1, interact with the autophagy kinase complexes proteins ATG1 ...

Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, United States ...

It does that by talking to the membrane fusion protein." More information: Chanwoo Lee et al, Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion, Nature ...

There are several mechanisms involved. The newly reported research has uncovered one mechanism, which they found is controlled by the mitochondrial protein MCJ. The researchers first identified ...