cellular senescence, inflammation, and fibrosis, whereas age-associated decline of microvascular endothelial cell density, satellite cell numbers, and muscle fiber types in skeletal muscle is ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metabolic requirements of dividing hepatocytes ...

"Our findings reveal for the first time that glycolysis-derived H3K14 lactylation (H3K14la) plays a key role in endothelial dysfunction by regulating the transcription of ferroptosis-related genes ...

Endothelial dysfunction and inflammation have been implicated in the pathophysiology of cerebral small vessel disease (SVD). However, whether they are causal, and if so which components of the ...

Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA damage ...

Single-cell RNA sequencing also revealed that specific cell types, such as endothelial cells and macrophages, exhibited higher senescence-related gene expression after PAGln treatment. In the ...

Endothelial dysfunction is one manifestation of the many changes induced in the arterial wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 diabetes ...

In terms of vascular health, SKM fibers regulate surrounding endothelial cells by secreting numerous angiogenic factors, some of which are encapsulated in EVs. Nie et al. demonstrated that C2C12-EVs ...