"Our findings reveal for the first time that glycolysis-derived H3K14 lactylation (H3K14la) plays a key role in endothelial dysfunction by regulating the transcription of ferroptosis-related genes ...

Single-cell RNA sequencing also revealed that specific cell types, such as endothelial cells and macrophages, exhibited higher senescence-related gene expression after PAGln treatment. In the ...

Endothelial dysfunction is one manifestation of the many changes induced in the arterial wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 diabetes ...

In terms of vascular health, SKM fibers regulate surrounding endothelial cells by secreting numerous angiogenic factors, some of which are encapsulated in EVs. Nie et al. demonstrated that C2C12-EVs ...

It alleviates the entire process of atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, and inhibiting platelet activation and aggregation. Additionally, GA can treat ...

Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.