Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

This built-in safeguard allows germinal centers to mass-produce successful clones without compromising antibody quality. The findings, published in Nature , solve the paradox of how the immune ...

Study reveals B cells suppress mutations during rapid division, enhancing immune response and offering critical insights for ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a ...

1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. 2Human Oncology Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, ...

Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this ...