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When the protein is not working correctly, it’s unable to help move chloride — a component of salt — to the cell surface ... Two major initiatives are helping with this mission. To make meaningful ...

While 'R' was also yellow, it had been ruled out in every position but first, essentially making it green. That only left one option. I typed in REVUE and completed the puzzle in four moves.

The solution turns brown. This brown colour is the displaced bromine. The chlorine has gone to form sodium chloride.