assemble focal adhesions and display tissue phenotypes characteristic of MECs interacting with a stiff matrix. Such observations underscore the importance of integrin signalling and Rho-dependent ...

During CP+ 2025, Sony unveiled a new wide angle prime lens – and the new optic is both shorter and more affordable than the brand’s next closest lens. The Sony 16mm f/1.8 G is an ultra-wide compact ...

Focal dystonia is a neurological disorder involving involuntary spasms and cramping in muscles, such as the hands and fingers. It can result from overuse and tends to affect musicians, golfers, or ...

In senescent cells, these focal adhesions become abnormally large and strong. The researchers found that AP2A1 helps transport a protein called integrin β1 along stress fibers to build and maintain ...

University of Maribor, Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, Smetanova ulica17, 2000 Maribor, Slovenia Members of the European Polysaccharide ...

the integrin clustering doesn’t really happen,” Cooper said. The Cas-depleted cells attached poorly to surfaces and were immobile. "It really nicely revealed all the sequence and dependence of very ...

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate ...

Intracellular syndecan domains activate signaling with PKCα (P) and via binding to PDZ-motif proteins. Integrin activation recruits a host of focal adhesion components, including integrin-binding ...

In the present review, we focus on the cellular mechanical response through ECM-integrin-cytoskeleton-nucleus axis and critically discuss the molecular basis of focal adhesion cell mechanosensing. We ...

Despite compromised integrin activation and adhesion, Mn 2+ enabled talin- but not kindlin-deficient cells to initiate spreading on FN. This isotropic spreading was induced by the ability of kindlin ...

1–3 Rat aortic rings were incubated with Texas red-conjugated heparin probes, embedded in tissue freezing medium and frozen. Aortic ring slices were labeled with anti-M 3 and/or anti-α 5 integrin and ...