The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

"Some people may leave our platforms for virtue signaling, but I think the vast majority and many new users will find that these changes make the products better." Zuckerberg was replying to a ...

High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). Fibroblasts have been in the ...

Zuck/Threads “Some people may leave our platforms for virtue signaling, but I think the vast majority and many new users will find that these changes make the products better,” Zuckerberg wrote.

As discussed below, anti-integrin therapies may represent such a novel anti-invasive therapy.

Notably, RPE-1 cells with heterozygous deletion of the U-box domain show altered TGFB signaling responses ... a very C-terminal ubiquitin-binding U-box domain that may regulate ciliary ubiquitination ...

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518055, P.