Following the discovery of inhibitory KIR and the understanding that they play a role in preventing NK cell killing of self MHC I-expressing tumor cells, investigators began to research the ...

The presence of HLA class I molecules, which interact with inhibitory KIRs on NK cells to limit their ... an E3 ubiquitin protein ligase, inhibits NK cell cytolytic activity and thereby improves ...

In AML, NK cell function is significantly compromised ... including the overexpression of inhibitory receptors like KIRs and ...

Overview of current approaches to improve effectiveness of adoptive transfer of NK cells by manipulation of the NK cell product, the host and the target. Human NK cells are a subset of peripheral ...