SPP1+ macrophages identified as key drivers and therapeutic targets in colorectal cancer progression
Interestingly, this study noted an increase in the proportion of M1 macrophages and a decrease in M2 macrophages in CRC, contradicting the M1/M2 polarization theory. Functional analyses suggests ...
Researchers focused particularly on the role of M1 and M2 macrophages ... pro-inflammatory M1 macrophages secreted factors that increased the expression of stem cell markers such as NANOG, KLF4 ...
SPP1+ Macrophages Identified as Key Drivers and Therapeutic Targets In Colorectal Cancer Progression
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.
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