This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Using genome-wide meta-analyses of clinical measures of depression and biobank data, the authors investigate symptom-specific genetic associations between depression and subsequent risk for ...

Uncertainty: one-way sensitivity and threshold analysis ICER: genotype directed dosing dominates usual care. Genotyping cost CDN$663 and usual care CDN$677 per patient. NNT for genotyping was 20 ...

Dysregulation of TGFβ signaling leads to aberrant vascular patterning and angiogenesis during mouse embryogenesis. Pathway activation involves phosphorylation ... Control and knockout embryos were ...

Methods: T-Rex Chinese hamster ovary cells transfected with the human LDLR gene were used for live cell imaging microscopy, flow cytometry, and qRT-PCR analysis. Results ... To determine LDLR plasma ...

2015). Next generation sequencing (NGS) is advantageous because there is no need to normalize the PCR for producing robust zygosity data, which could be a tool for high-throughput transgenic genotype ...