Molecular motors in action: visualizing alpha-cyclodextrin movement along polymer chains
Imagine a microscopic locomotive moving back and forth along a track, propelling itself without any external force. At the molecular level, this concept forms the foundation of molecular motors -- ...
Medscape4d
Polymer–Drug Conjugates for Novel Molecular Targets
PEG-Naloxol (NKTR-118) in Phase II clinical trials. Clinical benefit has already been demonstrated with polymer–drug conjugates bearing classical chemotherapeutic agents. The future of cancer ...
Purdue University6y
in animals with spinal injuries
The polymer, called polyethylene glycol or PEG, works by "fusing" the membranes of damaged nerve cells, and it can be applied up to eight hours after the injury without adversely affecting the patient ...
Nature5mon
Effect of pegylation on pharmaceuticals
For the past 30 years, scientists have improved various chemistries to build PEG polymers and attach them to a polypeptide drug of choice. Among the first pegylated drugs approved by the FDA in ...
Medscape3y
Polymer–Drug Conjugates for Novel Molecular Targets
Recent studies have already reported the use of polymer conjugation techniques with ... Oxidized dextran; PEG: Poly(ethylene glycol); PGA: Poly-L-glutamic acid; PTX: Paclitaxel.
EurekAlert!6d
Molecular motors in action: visualizing α-cyclodextrin movement along polymer chains
Fast-scanning atomic force microscopy imaging of the molecule at two different time points shows positional shifts along the polymer chain on the left. On the right, the molecular structure of PEG ...
Phys.org6d
Molecular motors in action: Visualizing α-cyclodextrin movement along polymer chains
"Although PEG@α-CD polypseudorotaxane is widely used, the structural changes that occur as α-CD rings shuttle along the polymer chain remain poorly understood. By revealing its structure at the ...