Both the lipid and protein composition of the endosome changes along the pathway to lysosomes (Box 1). Figure 1: A schematic of the ESCRT machinery involved in sorting cargo to lysosomes via MVBs.

Endosomes act as "sorting stations" inside cells ... which plays a vital role in regulating endosome maturation. This gene encodes a deubiquitinating enzyme that removes ubiquitin tags from ...