Macrophages represent one of the most prevalent cells in the colorectal cancer microenvironment and play a pivotal role in maintaining intestinal health and the development of colitis-associated colon ...

Whether and how iron-specific proteins (Tfr1, Tfr2, transferrin, etc.) in non-hepatocyte cells regulate the crosstalk ... associated with ineffective erythropoiesis (i.e. β-thalassemia and MDS). Given ...

In addition to excessive lipid peroxidation, iron overload is one of the features of ferroptosis. Ferritin heavy chain 1(FTH1) and Transferrin receptor protein 1 (TfR1) delicately regulate the storage ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical ...

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Coal worker’s ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In summary, synthesis of GMSs was undertaken using the emulsion ...

Detailed molecular characterization revealed that mosaic loss of Y chromosome promoted macrophage polarization toward a pro-fibrotic phenotype through enhanced TGF-β1 signaling. The causative role of ...

为探究自噬在铁死亡中的作用，研究人员开展相关研究，发现其影响因细胞环境而异，对理解细胞死亡机制意义重大。 铁死亡，作为一种铁依赖性的细胞死亡方式，近年来吸引了众多科研人员的目光。以往，人们普遍认为它与自噬紧密相连，然而，随着研究的 ...