最近的研究发现ECSIT在非免疫细胞和免疫细胞中对肿瘤发生有重要影响。肠道上皮细胞中ECSIT的缺失引起线粒体功能损伤并促进代谢重编程，谷氨酸代谢增加引起α-酮戊二酸/琥珀酸比率升高，进而促进TET去甲基化酶激活并诱导选择性翻译起始因子eIF4A1/ ...

We know polysaccharides initiating proliferation cycle, while other carbohydrates have a direct influence on the differentiation process towards barrier cells. Other carbohydrates can activate energy ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals ...

Day of Atonement; the scapegoat; the eating of blood forbidden; civil and religious laws; immorality forbidden We should also forgive and choose not to remember offenses against ourselves or others.

Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

PELO–HBS1L and SKI complexes in the human mRNA quality control pathway exhibit a synthetic lethal interaction and may represent novel targets for the development of cancer therapies.

With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which ...

Optimized lentiviral transduction enhances gene delivery in human iPSC-derived lung organoids, enabling advanced mechanistic studies in development and disease through improved protocols validated ...