Objective Due to lack of information on drug use in children, many drugs are used off-label in paediatrics. Increased knowledge of adverse drug reactions (ADRs) would enable a better risk–benefit ...

Background The gold standard for diagnosis of meningitis is the isolation of a pathogen from cerebrospinal fluid (CSF) by culture or PCR. However, treatment is routinely commenced based on CSF ...

Charts are presented which give centile standards for boys' and girls' heights at ages 2 to 9 when parents' height is allowed for. Mid-parent height is used (i.e. the average of father's and mother's ...

2 Department Community Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK 3 Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, ...

Objective The critical importance of a secure mother-infant attachment relationship for long-term physical and mental health of the child is well established. Our study aim was to explore mothers’ ...

Objective To evaluate long-term associations between early childhood hyperactivity and conduct problems (CP), measured using Strengths and Difficulties Questionnaire (SDQ) and risk of injury in early ...

Objective To determine whether infants with severe persistent sleep problems are at increased risk of (1) meeting diagnostic criteria for a psychiatric disorder (age 10 years), and (2) having elevated ...

Objective To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of ...

Hospitalised children predate 19th-century specialist children’s hospitals. Before Lister and anaesthesia, surgery was generally of short duration. In the 18th century, paediatric surgery was ...

Objective To develop an Overall Pediatric Health Standard Set (OPH-SS) of outcome measures that captures what matters to young people and their families and recognising the biopsychosocial aspects of ...

5 Dalla Lana School of Public Health, University of Toronto, Toronto, Canada 6 Departments of Paediatrics, Obstetrics and Gynaecology and Health Policy, Management and Evaluation, University of ...

Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation ...