Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

1 Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA 2 Division of Biostatistics, Mayo Clinic and Foundation, Rochester, MN, USA Correspondence to: Dr E V ...

Correspondence to Julien Kirchgesner, Service de Gastroentérologie et Nutrition, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris, 184 rue du faubourg Saint-Antoine, Paris 75012, France; ...

Objective To determine whether new users of proton pump inhibitors (PPIs) are at an increased risk of gastric cancer compared with new users of histamine-2 receptor antagonists (H2RAs). Design Using ...

BACKGROUND Topical nitrates lower anal sphincter pressure and heal anal fissures, but a majority of patients experience headache. The internal anal sphincter has a calcium dependent mechanism to ...

Correspondence to: Dr E E Frezza Department of Surgery, Division of General Surgery, Texas Tech University Health Sciences Center, MOP Building, Suite 380, 3502 9th St, Lubbock, Texas 79415, USA; eldo ...

Objective Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble ...

Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Conclusion Our ...

2 Department of Gastroenterology, St Mark’s Hospital, Harrow, UK 3 Department of Gastroenterology, Llandough Hospital, Penarth, UK 4 Department of Gastroenterology, St James’s University Hospital, ...

The aim of this study was to establish the relative importance of risk factors for mortality after acute upper gastrointestinal haemorrhage, and to formulate a simple numerical scoring system that ...

Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...

Dr Helmut Friess, Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, CH-3010 Bern, Switzerland. Email: helmut.friess{at}insel.ch BACKGROUND Nerve growth factor (NGF), ...