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Role of the Brain’s Reward Circuitry in Depression: …
Here we focus on the nucleus accumbens (NAc), a critical component of the brain’s reward circuitry, in depression and other stress-related disorders. The prominence of anhedonia, reduced motivation, and decreased energy level in most individuals with depression supports the involvement of the NAc in these conditions.
Prefrontal cortex circuits in depression and anxiety ... - Nature
2020年2月21日 · Recently developed optogenetic and chemogenetic tools that allow high-fidelity control of neuronal activity in preclinical models have begun to elucidate the contributions of the PFC and its...
Toward Circuit Mechanisms of Pathophysiology in Depression
2020年5月1日 · In these circuit-focused frameworks, monoamine neuromodulators are still key players in depression pathophysiology, in that they exert a powerful influence on circuit function, but monoamine-targeting antidepressants are thought to achieve their therapeutic effects by engaging plasticity mechanisms, remodeling synaptic connectivity, and ...
Neural Circuits Underlying the Pathophysiology of Major Depression
2022年2月12日 · Recent research in patients and preclinical animal models has focused on identifying the neural circuits that mediate separable characteristics of depression, and connections between the prefrontal cortex (PFC) and subcortical regions such as the dorsal raphe nucleus (DRN) and the ventral tegmental area (VTA) have emerged as candidate targets.
Precision psychiatry: a neural circuit taxonomy for depression …
This synthesis provides the foundation for a taxonomy of putative types of dysfunction, which cuts across traditional diagnostic boundaries for depression and anxiety and includes instead distinct types of neural circuit dysfunction that together reflect the …
Neuronal correlates of depression - PubMed
Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms.
Neural Circuitry of Depression | Neurobiology of Mental Illness ...
Beginning in the 1970’s and 1980’s and continuing through the last 15 years, neuroanatomical techniques based on axonal transport have been applied extensively to the limbic system and prefrontal cortex of monkeys.
Wiring the depressed brain: optogenetic and chemogenetic circuit ...
2018年12月5日 · Optogenetic tools have been key to mapping the circuitry underlying depression-like behavior in animal models, clarifying the contribution of the ventral tegmental area, nucleus accumbens,...
focus on functional imaging of circuit dysfunctions across the spectrum of mood and anxiety disorders. This synthesis provides the foundation for a taxonomy of putative types of dysfunction, which cuts across traditional diagnostic boundaries for depression and anxiety and includes instead distinct types of neural circuit dysfunction that together
The molecular and cellular mechanisms of depression: a focus
2019年4月9日 · Altered reward circuit function is theorized to underlie the loss of pleasure and amotivational syndrome experienced by most MDD patients, and many studies have strived to uncover the...