Acromegaly is a rare disorder caused by too much growth hormone (GH) secreted by the anterior pituitary gland, a small organ at the base of the brain. In children, too much GH can lead to gigantism condition characterized by unusually tall stature.

Acromegaly is a rare disorder caused by too much growth hormone (GH) secreted by the anterior pituitary gland, a small organ at the base of the brain. In children, too much GH can lead to gigantism condition characterized by unusually tall stature.

In adults, excess growth hormone causes a different disorder, called acromegaly, because their long bones have stopped growing. Let’s start with how growth hormone, or somatotropin, is made.

Acromegaly, often caused by a benign pituitary adenoma, manifests as a broad range of signs, symptoms, and comorbidities caused by the tumor (headaches and visual field defects) and by the long-term effects of GH/IGF-1 hypersecretion on multiple organs and tissues.

Acromegaly is a rare disease with prevalence of approximately 60 cases per million, slight female predominance and peak onset in adults in the fourth decade. Clinical diagnosis is often delayed by several years due to the slowly progressive onset of symptoms.

In this Review, we examine the epidemiology, pathogenesis, diagnosis, complications, and treatment of acromegaly, with an emphasis on the importance of tailoring management strategies to each patient to optimise outcomes.

Gigantism and acromegaly are syndromes of excessive secretion of growth hormone (hypersomatotropism) that are nearly always due to a pituitary adenoma. Before closure of the epiphyses, the result is gigantism. Later, the result is acromegaly, which causes distinctive facial and other features.

2020年9月25日 · Acromegaly is a disorder caused by excessive growth hormone production from the anterior pituitary gland, resulting in excessive growth of body tissues and other metabolic dysfunctions. The causes of acromegaly can be divided into primary GH excess, ectopic or iatrogenic GH excess, and excess growth hormone-releasing hormone (GHRH).

Gigantism and acromegaly are usually caused by a pituitary adenoma that secretes excessive amounts of Growth Hormone; rarely, they are caused by non-pituitary tumors that secrete GHRH Gigantism occurs if growth hormone (GH) hypersecretion begins in childhood, before closure of the epiphyses Acromegaly involves growth hormone GH hypersecretion beginning in adulthood; a variety of bony and soft ...

2022年11月1日 · In this Review, we examine the epidemiology, pathogenesis, diagnosis, complications, and treatment of acromegaly, with an emphasis on the importance of tailoring management strategies to each patient to optimise outcomes.