Corneal endothelial decompensation leads to ‘overhydration’ of the cornea, known as corneal edema, or in the advanced stage, bullous keratopathy. The patient may be asymptomatic in the early stage. As the corneal edema progresses, there may be glare or blurred vision caused by folds in Descemet’s membrane and increased stromal thickness.

We identified patients with corneal opacity using International Classification of Diseases (ICD), Ninth and Tenth Revisions, codes of 371 (corneal scar) and H17 (corneal opacity), respectively. The analyzed data comprised demographic parameters including age, sex, race, ethnicity, and geographical location.

2021年5月1日 · Injury to the corneal endothelium during intraocular surgery can lead to endothelial decompensation, resulting in corneal edema and potentially the formation of epithelial blisters (bullae), a condition known as bullous keratopathy. Cataract surgery is by far the most common ocular surgical procedure.

HLA antigens located in the plasma membrane may participate in corneal endothelial graft rejection. Clinical assessment of the endothelium involves three modalities: specular microscopy to study endothelial morphology, fluorophotometry to measure barrier function, and pachymetry to measure corneal thickness. This paper is only available as a PDF.

Corneal neovascularization, trauma and, surgical procedures such as photorefractive keratectomy and graft rejection after penetrating keratoplasty can lead to corneal opacification. In this article we identify the underlying basis of corneal transparency and …

Many corneal opacities start as persistent, nonhealing epithelial defects that opacify as a result of infection, inflammation, tissue breakdown, and/or scarring. Nerve growth factor has been shown to be effective in treating nonhealing epithelial defects in the setting of neurotrophic keratopathy.

Corneal opacity is a leading cause of vision loss. 1 Monocular blindness, attributable to corneal opacity from trauma or corneal ulceration, was estimated to occur with a worldwide incidence of 1.5 to 2.0 million cases per year in 2001. 1 Corneal opacity can occur after trauma, chemical injuries, infections, surgeries , or secondary to other ...

2024年1月6日 · Corneal endothelial dysfunction can lead to corneal edema, opacity, and even blindness. Due to the limited proliferative capacity of human CECs and the global shortage of donor cornea, corneal endothelial regeneration and replacement always represent the most challenge in the basic research and clinical treatment of corneal diseases.

2018年10月23日 · Many corneal opacities start as persistent, nonhealing epithelial defects that opacify as a result of infection, inflammation, tissue breakdown, and/or scarring. Conventional treatment of an epithelial defect involves the use of an antibiotic drop or ointment that will protect against secondary bacterial infection.

In this study, we aimed to document the corneal endothelial changes and their correlations with mean intraocular pressure between POAG patients and normal controls. We found that the corneal endothelial cell density in POAG patients is decreased and the average endothelial cell area is increased compared with those in healthy controls.