Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD), characterized by atrophic lesions that first start in the outer retina and progressively expand to cover the macula and the fovea, the center of the macula, leading …

In simple terms, Geographic Atrophy (GA), is an advanced form of dry age-related macular degeneration (AMD) that causes cell death (atrophy) in areas of the retina and can lead to irreversible vision loss.

High-resolution histology at the border of geographic atrophy (or complete retinal pigment epithelium and outer retinal atrophy) secondary to age-related macular degeneration reveals marked gliosis and near-total photoreceptor depletion, abundant extracellular deposits, and long-standing abnormalities of Bruch membrane and choriocapillaris ...

2017年3月28日 · Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) that leads to progressive and irreversible loss of visual function. Geographic atrophy is defined by the presence of sharply demarcated atrophic lesions of the outer retina, resulting from loss of photoreceptors, retinal pigment epithelium (RPE), and ...

2023年4月5日 · Geographic atrophy is the last stage of dry age-related macular degeneration. Researchers don’t know for certain what causes the changes in your eye that lead to geographic atrophy, but they think that part of your immune system called …

On the atrophic side of the ELM descent, all measures of photoreceptor health declined to zero. Henle fiber layer/outer nuclear layer thickness halved, and only Müller cells remained, in the absence of photoreceptors. Sub-RPE deposits remained, Bruch membrane thinned, and choriocapillaris density decreased.

2024年10月29日 · Geographic atrophy (GA) is the non-neovascular late stage of age-related macular degeneration (AMD). It is characterized by the irreversible loss of retinal pigment epithelium (RPE ...

2023年4月10日 · In age-related macular degeneration (AMD), the development of geographic atrophy (GA) differs partially but fundamentally from its subsequent expansion: in its time-course, its risk factors, and its underlying mechanisms. Across the life cycle of GA, its conception and gestation differ in notable ways from its infancy and adulthood.

2023年9月1日 · In age-related macular degeneration (AMD), the development of geographic atrophy (GA) differs partially but fundamentally from its subsequent expansion: in its time-course, its risk factors, and its underlying mechanisms. Across the life cycle of GA, its conception and gestation differ in notable ways from its infancy and adulthood.

2020年10月18日 · On OCT, progression of intermediate AMD to atrophy is usually associated with RPE and outer retinal layer loss, choroidal hypertransmission, and drusen regression. Furthermore, specific drusen characteristics and other anatomic features that constitute risk factors for progression to atrophy have been identified, as described below. 5–8.