2011年12月16日 · Loss of the GJA1 -encoded gap junction channel protein connexin43 is known to underlie formation of lethal arrhythmias. GJA1 mutations have been associated with cardiac diseases, including atrial fibrillation. Therefore, GJA1 is …

Connexin43 (Cx43) expression was heterogeneous with a higher prevalence of non-phosphorylated Cx43 in arrhythmogenic TAC animals. In TAC rats with compensated cardiac hypertrophy, dispersion of conduction correlated to arrhythmogenesis, an increased heterogeneity of Cx43, and a partial substitution with non-phosphorylated Cx43.

2012年8月1日 · This suggests that heterogeneous reduction of Cx43, which is related with the presence of ventricular tachycardia and late ventricular potentials, may play a role in development of ventricular arrhythmias in DCM patients, possibly reflecting the patient's arrhythmic risk.

2012年4月1日 · The main finding of this study is that in the background of very low (∼5%) Cx43 levels, differences in tissue characteristics determine arrhythmia susceptibility in individual mice: severely reduced Cx43 protein levels with large regions of total depletion of Cx43, leading to global, but not local, heterogeneity of Cx43 expression.

Global heterogeneity in Cx43 expression and concomitant heterogeneous downregulation of sodium-channel protein expression and sodium current leads to slowed and dispersed conduction, which sensitizes the heart for ventricular arrhythmias.

Relative Cx43 expression was heterogeneously distributed and lower (by 32 +/- 18%, P < 0.05) in the subepicardium compared with deeper layers. Reduced Cx43 expression in heart failure was associated with significant reductions in intercellular coupling between transmural muscle layers, as evidenced by reduced theta(TM) (by 18.9 +/- 4.9%) and ...

2023年2月22日 · In conclusion, we provide evidence that recovery of Cx43 cytoskeleton based forward trafficking after GJA1-20k gene therapy improves gap junction localization and reduces ventricular arrhythmias in a mouse model of ACM, independent of systolic dysfunction, or …

2012年4月1日 · The main finding of this study is that in the background of very low (∼5%) Cx43 levels, differences in tissue characteristics determine arrhythmia susceptibility in individual mice: severely reduced Cx43 protein levels with large regions of total depletion of Cx43, leading to global, but not local, heterogeneity of Cx43 expression.

2011年11月22日 · Background - Reduced Cx43 levels are associated with an increased vulnerability to arrhythmias. We hypothesized that induced Cx43 downregulation of conditional Cx43 KO mice results in more severe and heterogeneous reduction of Cx43, together with decreased Nav1.5 expression, in mice with spontaneous and induced ventricular arrhythmias.

Heterogeneous expression of the principal ventricular gap junction protein connexin43 (Cx43) is associated with action potential duration (APD) dispersion across the anterior ventricular wall. Little is known about Cx43 expression patterns and their disparate impact on regional electrophysiology throughout the heart.