2022年3月15日 · Insulin improved verbal fluency and clinical measures of PD severity compared to placebo. One patient with MSA remained stable on insulin treatment (Novak et al., 2019). The same investigators reported that nasal insulin improved walking speed, executive function, and verbal memory in older people with or without Type 2 diabetes (Novak et al ...

2007年7月12日 · A: Certainly some amount of peptide following nasal delivery is absorbed into the blood stream via the nasal, bronchial and alveolar epithelium. However, we measured peptide concentrations after nasal administration concurrently in blood and found that, except for vasopressin, the concentrations were negligible compared with those in CSF.

2023年1月18日 · The nasal spray delivers oxytocin to the brain, where it is reported to last for several hours (see review by Quintana et al., 2021). Oxytocin is proposed as a symptomatic treatment for people with frontotemporal dementia, where damage to the frontal and temporal lobes impairs emotional processing, social cognition, and behavior.

2024年11月22日 · These responses could be due to chance in this small sample. Or they could reflect immune communication between the CNS and periphery via the nasal olfactory plexus, Craft believes. Positioned behind the nasal cavity, this structure is an immune hub and part of the glymphatic system (for review, see Chae et al., 2024). Craft hopes her approach ...

2011年9月15日 · A Phase 2 trial of intranasal insulin for Alzheimer’s disease was published online September 12 in the Archives of Neurology. First author Suzanne Craft of the University of Washington, Seattle, previously reported key findings from this double-blind, four-month trial last summer at the International Conference on Alzheimer’s Disease in ...

Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J Alzheimers Dis. 2015 Jan 1;44(3):897-906. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease. Alzheimers Dement. 2014 Feb;10(1 Suppl):S33-7. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

2018年11月20日 · The study enrolled 289 volunteers with MCI or mild AD, who took 20 units twice a day of insulin or placebo. The primary outcome was their ADAS12-Cog score, measured quarterly. They started out using Kurve Technology’s ViaNase spray device, the same as in …

2010年7月30日 · Aptly named SNIFF-120 (Study of Nasal Insulin to Fight Forgetfulness), this double-blind Phase 2 trial was funded by the National Institute on Aging. Participants were randomized into three roughly equal groups that received saline placebo or insulin (20 or 40 IU) through the nose each day, and underwent cognitive testing at baseline, two ...

First Biodistribution Study of [68Ga]Ga-NOTA-Insulin Following Intranasal Administration in Adult Vervet Monkeys. J Alzheimers Dis . 2024;101(1):309-320. PubMed .