2023年1月2日 · Integrin αvβ6 primarily binds with TGF-β, fibronectin, osteopontin, and a disintegrin and metalloproteinase (ADAM). 52,66 It is an important activator of TGF-β, which regulates innate...

A: Integrin αvβ6 mediates TGF-β activation through a mechanism requiring mechanical tension, facilitated by covalent linkage of the SLC to the latent TGF-β binding protein (LTBP) and to ECM proteins. This tension opens LAP, rendering the mature TGF-β peptide accessible to the TGF-β receptor (TGF-βR) expressed by an adjacent epithelial cell.

2020年2月6日 · Using cryo-electron microscopy, structure-guided mutagenesis, and cell-based assays, we reveal the binding interactions between the entire αvβ8 ectodomain and its intact natural ligand, L-TGF-β, as well as two different inhibitory antibody fragments to understand the structural underpinnings of αvβ8 binding specificity and TGF-β activation.

2021年9月1日 · TGF-β is secreted in the tumour microenvironment in a latent, inactive form bound to latency associated protein and activated by the integrin α V subunit. The activation of latent TGF-β by...

2020年2月6日 · Using cryo-electron microscopy, structure-guided mutagenesis, and cell-based assays, we reveal the binding interactions between the entire αvβ8 ectodomain and its intact natural ligand, L-TGF-β, as well as two different inhibitory antibody fragments to understand the structural underpinnings of αvβ8 binding specificity and TGF-β activation.

2022年8月25日 · Integrin α V β 8 activates extracellular L-TGF-β1 to trigger the downstream signaling functions. However, the mechanism designating the specificity of TGF-β1 presentation and activation...

Mutant mice defective in integrin-mediated activators, and humans and mice with fibrillin gene mutations, show the critical role of ECM and integrins in regulating TGF-β signaling. TGF-β is synthesized by, and can signal to, essentially all cells.

2019年11月16日 · Integrins control spatiotemporal activation of latent TGF-β in extracellular matrix or cell-surface reservoirs. Integrin αvβ8 is constitutively active, binds latent TGF-β with extremely high affinity, and activates TGF-β using a chaperone protein.

2015年5月19日 · Here we show that Foxp3 + Treg cells are specialized activators of TGF-β via expression of the integrin αvβ8 and that expression of the integrin is upregulated on activated/effector (e)Treg cells, indicating a potential role in Treg-cell-mediated modulation of active inflammation.

2010年1月15日 · Accumulating evidence indicates that there is extensive crosstalk between integrins and TGF‐β signalling. TGF‐β affects integrin‐mediated cell adhesion and migration by regulating the expression of integrins, their ligands and integrin‐associated proteins. Conversely, several integrins directly control TGF‐β activation.