Skeletal fluorosis is a bone disease caused by excessive accumulation of fluoride leading to weakened bones. [1] In advanced cases, skeletal fluorosis causes painful damage to bones and joints.

Skeletal fluorosis is a debilitating bone disease caused by excessive accumulation of fluoride in the bones. Despite being a preventable condition, it remains a significant health concern in various parts of the world, particularly in areas with high levels of fluoride in drinking water.

Endemic skeletal fluorosis is a chronic metabolic bone and joint disease caused by ingesting large amounts of fluoride either through water or rarely from foods of endemic areas. Fluoride is a cumulative toxin which can alter accretion and resorption of bone tissue.

Skeletal (bone) fluorosis affects your bones and joints. It can have a negative impact on your overall health, resulting in osteoporosis, arthritis and chronic joint pain. It happens when you have chronic fluoride overexposure for many years. Non-skeletal fluorosis is …

Skeletal fluorosis (SF) is endemic primarily in regions with fluoride (F)-contaminated well water, but can reflect other types of chronic F exposure. Calcium (Ca) and vitamin D (D) deficiency can exacerbate SF.

Skeletal fluorosis is defined as skeletal changes due to long-term ingestion of excessive fluoride and it may include hyperostosis and osteoporosis. This phenomenon is detectable when drinking water contains 3–6 mg fluoride l −1 .

2023年10月10日 · The bones and major joints of the body, such as the neck, backbone, shoulder, hip, and knee joints, are affected by skeletal fluorosis, which causes severe joint pain, rigidity, or stiffness. Severe forms of skeletal fluorosis are associated with significant impairment.

2024年4月20日 · Prolonged, excessive exposure to fluoride can cause a debilitating bone disease known as skeletal fluorosis. The disease develops insidiously and can be difficult to distinguish from a number of other bone and joint diseases.

2024年6月7日 · Skeletal fluorosis (SF) results from chronic exposure to fluoride (F−) causing excessive aberrantly mineralized brittle bone tissue, fractures, and exostoses. There is no established treatment other than avoiding the source of F−. Still, excess F− can persist in bone for decades after exposure ceases.

2019年9月9日 · Skeletal fluorosis is a rare toxic osteopathy characterized by massive bone fixation of fluoride. The disease occurs as an endemic problem in some parts of the world and is the result of prolonged ingestion or rarely by inhalation of high amounts of fluoride.